Among hospital settings, surgical site infections (SSIs) are a main contributor to Healthcare Associated Infections (HAIs). Dissemination of microorganisms around SSIs can occur through the transfer of microorganisms from the patient’s surrounding skin or the skin of the healthcare professional.
SSIs can be avoided if conscientious hygiene procedures are practiced. Clinicians have used numerous strategies to combat wound infections, including topical and systemic administration of antibiotics, and various antiseptic agents such as hypochlorite (bleach) and hydrogen peroxide have been placed on wounds to kill bacteria or inhibit their growth. In contrast to these other agents, molecular iodine can treat skin such to make it bactericidal. This is due to the hydrophobic nature of I2.
A commonly used antimicrobial agent is povidone-iodine (Betadine), a complex of molecular iodine with polyvinylpyrrolidone (povidone), a synthetic polymer. The most common commercial form is a 10% solution in water yielding 1% available I2. Povidone-iodine (PVP-I) is also used as a surgical scrub or skin cleanser with a detergent base (0.75% available I2). Molecular iodine is the only iodine species which diffuses into skin since, unlike the other species in iodophors, I2 is hydrophobic. Outgassing of I2 from the skin can be measured for at least 24 hours following administration of Iogen's proprietary emollients. Controlled experiments have demonstrated the ability of the outgassing I2 to kill bacteria held in a suspension above the surface of treated skin. No soap, alcohol, chlorhexadine, or iodophore based formulation can match Iogen emollients' duration of microbicide activity and safety profile.
Iogen’s preferred I2 wound care treatment promises to retard wound progression and support the stages of healing (inflammatory, proliferative/reepithelializing, and remodeling). Efficacy studies evaluating our wound anticeptic have shown a sustained cidal capacity in vitro that is more effective that standard providone-iodine.